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Females with triple X syndrome often have delayed language development. Symptoms may include tall stature , vertical skin folds that may cover the inner corners of the eyes epicanthal folds , poor muscle tone, and a curve in the 5th finger towards the 4th. Triple X syndrome can be diagnosed prenatally through amniocentesis or chorionic villus sampling. Because of the lyonization , inactivation, and formation of Barr bodies in all female cells, only one X chromosome is active at any time. Archived from the original on 27 July In some cases, trisomy X occurs during cell division in early embryonic development. If one of these cells contributes to the genetic makeup of a child, the child will have an extra X chromosome in each of her cells. Poor coordination may be present. On average, five to ten girls with triple X syndrome are born in the United States each day.

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